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上海酶聯生物研究所
上海酶聯生物研究所
閱讀：896發布時間：2010-4-9
*昆明動物研究所賴仞研究員與*上海藥物研究所林東海研究員領導的研究團隊在多肽類抗氧化系統研究方面再獲新進展。
2009年，該研究團隊提出了基因編碼的多肽類抗氧化系統，并命名為“第三套”抗氧化系統。在“第三套”抗氧化系統工作的基礎上，該研究團隊從多肽類抗氧化系統對自由基的清除效率、速度以及作用機理進行了深入研究，結果表明抗氧化多肽可以非常快速地清除80%以上人造自由基（小于兩秒鐘），其速度是目前商業用抗氧化劑（如2，6-二叔丁基-4-甲基*和*）的2-4倍。抗氧化作用機制研究表明，抗氧化多肽序列中的還原性半*對快速地清除自由基起著關鍵作用。
該研究結果發表在美國《自由基生物醫學聯合會會刊》。
原文出處：
Free Radical Biology and Medicine doi:10.1016/j.freeradbiomed.2010.01.036
Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability
Cunbao Liua, b, 1, Jing Hongb, c, 1, Hailong Yanga, b, 1, Jing Wua, b, Dongying Maa, b, Dongsheng Lia, Donghai Linc, , and Ren Laia, d
a Biotoxin Unit of the Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
b Graduate School, Chinese Academy of Sciences, Beijing, China
c Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
d Key Laboratory of Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture, Life Sciences College, Nanjing Agricultural University, Nanjing, Jiangsu, China
The question of how amphibians can protect themselves from reactive oxygen species when exposed to the sun in an oxygen-rich atmosphere is important and interesting, not only from an evolutionary viewpoint, but also as a primer for researchers interested in mammalian skin biology, in which such peptide systems for antioxidant defense are not well studied. The identification of an antioxidant peptide named antioxidin-RL from frog （Odorrana livida） skin in this report supports the idea that a peptide antioxidant system may be a widespread antioxidant strategy among amphibian skins. Its ability to eliminate most of the 2,2′-azino-bis（3-ethylbenzthiazoline-6-sulfonic acid） radical tested within 2 s, which is much faster than the commercial antioxidant factor butylated hydroxytoluene, suggests that it has a potentially large impact on redox homeostasis in amphibian skins. Cys10 is proven to be responsible for its rapid radical scavenging function and tyrosines take part in the binding of antioxidin-RL to radicals according to our nuclear magnetic resonance assay.
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